| 8/18 | H | Beechwood (KY) (9-1) | [V] | L | 14-31 | |
| 8/25 | A | Wheelersburg (9-4) | [V:19] | L | 17-20 | |
| 9/1 | H | Goshen (3-8) | [III:12] | W | 35-7 | |
| 9/8 | A | Bishop Hartley (10-3) | [IV:15] | L | 3-49 | |
| 9/15 | H | Roger Bacon (6-5) | [IV:16] | W | 35-0 | |
| 9/22 | H | Chaminade Julienne (7-5) | [III:12] | W | 35-0 | |
| 9/29 | A | Archbishop Alter (12-4) | [IV:16] | L | 7-28 | |
| 10/6 | A | Bishop Fenwick (5-5) | [IV:16] | W | 35-14 | |
| 10/13 | H | Archbishop Carroll (2-8) | [III:12] | W | 49-14 | |
| 10/20 | H | Badin (13-1) | [III:12] | L | 35-38 | |
| 10/27 | A | # Eaton (8-3) | [IV:16] | W | 41-20 | |
| 11/3 | A | # Clinton-Massie (12-1) | [IV:16] | L | 23-24 | ot |
| # - Ohio playoff game | ||||||