| 8/18 | H | River Valley (0-10) | [V:19] | W | 55-6 | |
| 8/25 | H | Bishop Rosecrans (4-7) | [VII:27] | W | 40-7 | |
| 9/1 | A | South Gallia (7-4) | [VII:27] | W | 34-8 | |
| 9/8 | A | Notre Dame (8-4) | [VII:27] | W | 42-26 | |
| 9/15 | H | Waterford (8-5) | [VII:27] | W | 21-20 | |
| 9/22 | H | Tucker County (WV) (10-0) | [VII] | L | 22-28 | ot |
| 9/29 | A | Buffalo (Putnam) (WV) (0-10) | [VI] | W | 59-16 | |
| 10/6 | A | Trimble (6-5) | [VI:23] | W | 21-20 | |
| 10/13 | H | Belpre (1-9) | [VI:23] | W | 49-6 | |
| 10/21 | A | Southern (3-7) | [VII:27] | W | 48-13 | |
| 10/27 | H | # Berne Union (2-9) | [VII:27] | W | 48-0 | |
| 11/3 | H | # Monroe Central (7-5) | [VII:27] | W | 55-14 | |
| 11/10 | N | # River (9-3) | [VII:27] | W | 21-14 | |
| 11/17 | N | # Caldwell (11-4) | [VII:27] | L | 19-20 | |
| # - Ohio playoff game | ||||||