| 8/24 | H | Wellsville (5-5) | [6:23] | W | 19-0 | |
| 9/1 | A | Southern (2-8) | [6:23] | W | 24-0 | |
| 9/8 | H | St John Central (5-5) | [6:23] | W | 40-0 | |
| 9/16 | A | Bridgeport (0-9) | [6:23] | W | 41-12 | |
| 9/22 | H | Harrison Central (0-10) | [4:13] | W | 44-8 | |
| 9/29 | H | The Academy (PA) (0-5) | [5:0] | W | 40-0 | |
| 10/6 | H | Malvern (7-3) | [6:23] | W | 33-0 | |
| 10/13 | H | Wheeling Central Catholic (WV) (9-1) | [5:0] | W | 33-12 | |
| 10/21 | A | Conotton Valley (1-9) | [6:23] | W | 42-6 | |
| 10/27 | H | Catholic Central (3-7) | [5:19] | W | 30-6 | |
| 11/3 | A | # Beallsville (9-2) | [6:23] | W | 32-26 | |
| 11/10 | N | # Notre Dame (11-1) | [6:23] | W | 22-18 | |
| 11/17 | N | # Newark Catholic (9-5) | [6:23] | L | 0-34 | |
| # - Ohio playoff game | ||||||