| 8/26 | H | Fairfield (8-4) | [1:4] | W | 15-9 | |
| 9/1 | A | Princeton (6-4) | [1:4] | W | 36-18 | |
| 9/8 | H | Cathedral (IN) (10-1) | [2:0] | L | 13-17 | |
| 9/16 | H | St Ignatius (11-1) | [1:1] | L | 10-29 | |
| 9/22 | H | Indianapolis Arsenal Technical (IN) (3-8) | [1:0] | W | 45-0 | |
| 9/29 | A | Archbishop Moeller (9-2) | [1:4] | L | 16-22 | |
| 10/6 | H | La Salle (5-5) | [1:4] | W | 34-12 | |
| 10/13 | A | Elder (8-4) | [1:4] | W | 17-14 | |
| 10/20 | A | Archbishop McNicholas (7-4) | [2:8] | W | 42-14 | |
| 10/27 | A | Anderson (8-3) | [1:4] | W | 40-37 | |
| 11/4 | H | # Western Hills (9-2) | [1:4] | W | 42-7 | |
| 11/11 | N | # Colerain (13-1) | [1:4] | L | 30-35 | |
| # - Ohio playoff game | ||||||