| 8/18 | H | Indianapolis Cathedral (IN) (5-5) | [2:0] | W | 35-28 | |
| 9/2 | A | Bowling Green (0-1) | W | 30-19 | ||
| 9/8 | H | Fairdale (0-1) | W | 56-14 | ||
| 9/15 | A | Central (Louisville) (0-1) | W | 42-7 | ||
| 9/22 | A | Pleasure Ridge Park (0-2) | W | 35-21 | ||
| 9/29 | N | Trinity (Louisville) (10-0) | [1:0] | L | 0-28 | |
| 10/6 | A | DuPont Manual (0-1) | W | 56-34 | ||
| 10/13 | H | Male (Louisville) (0-2) | W | 27-0 | ||
| 10/20 | H | Butler (Louisville) (0-1) | W | 37-0 | ||
| 10/27 | H | St Xavier (OH) (11-2) | [1:4] | L | 14-16 |