| 8/26 | A | Hamilton (3-7) | [1:4] | W | 42-7 | |
| 9/2 | A | Trinity (Louisville) (KY) (10-0) | [1:0] | L | 30-38 | |
| 9/8 | A | Scott County (KY) (8-2) | [1:0] | W | 38-28 | |
| 9/15 | H | Lafayette (KY) (3-7) | [1:0] | W | 55-6 | |
| 9/22 | H | St Xavier (11-2) | [1:4] | L | 7-30 | |
| 9/29 | H | La Salle (10-3) | [2:8] | L | 24-28 | |
| 10/6 | A | Elder (6-4) | [1:4] | L | 14-42 | |
| 10/13 | N | St Ignatius (11-2) | [1:1] | W | 41-20 | |
| 10/21 | A | St Edward (10-2) | [1:1] | L | 7-31 | |
| 10/27 | A | Winton Woods (13-2) | [2:8] | L | 14-35 | |
| 11/3 | A | # Colerain (11-3) | [1:4] | L | 0-45 | |
| # - Ohio playoff game | ||||||