| 8/25 | A | Oak Hills (4-6) | [1:4] | W | 40-16 | |
| 8/31 | H | Withrow (3-6) | [1:4] | W | 42-14 | |
| 9/7 | A | Cathedral (IN) (7-3) | [2:0] | W | 21-0 | |
| 9/15 | H | Bethlehem Catholic (PA) (8-2) | [3:0] | W | 24-0 | |
| 9/28 | H | Archbishop Moeller (5-5) | [1:4] | W | 47-0 | |
| 10/5 | A | La Salle (1-9) | [1:4] | W | 35-10 | |
| 10/12 | H | Elder (11-2) | [1:4] | W | 16-13 | |
| 10/20 | A | St Ignatius (11-4) | [1:1] | W | 42-41 | |
| 10/26 | A | Hamilton (7-4) | [1:4] | W | 37-23 | |
| 11/3 | H | # Northmont (7-4) | [1:4] | W | 41-6 | |
| 11/10 | H | # Princeton (8-4) | [1:4] | W | 6-0 | |
| 11/17 | H | # Elder (11-2) | [1:4] | W | 24-21 | |
| 11/24 | H | # Dublin Coffman (9-4) | [1:3] | W | 35-14 | |
| 12/1 | A | # St Ignatius (11-4) | [1:1] | L | 6-37 | |
| # - Ohio playoff game | ||||||