| 8/20 | H | Archbishop McNicholas (11-2) | [IV:16] | L | 13-28 | |
| 8/27 | A | Northwest (3-7) | [III:12] | L | 21-34 | |
| 9/3 | H | Taft (9-3) | [V:20] | L | 15-30 | |
| 9/10 | A | Wyoming (12-1) | [IV:16] | L | 0-30 | |
| 9/17 | H | Mariemont (8-4) | [V:20] | W | 21-7 | |
| 9/24 | A | Taylor (5-6) | [IV:16] | W | 42-14 | |
| 10/1 | A | Madeira (4-7) | [V:20] | W | 28-7 | |
| 10/8 | H | Finneytown (3-7) | [V:20] | W | 68-6 | |
| 10/15 | A | Deer Park (4-8) | [VI:24] | W | 49-35 | |
| 10/22 | H | Reading (7-3) | [V:20] | L | 8-12 | |
| 10/29 | A | # Milton-Union (10-2) | [IV:16] | L | 0-33 | |
| # - Ohio playoff game | ||||||