| 9/6 | H | Aquinas Institute (9-0) | [4:0] | L | 8-32 | |
| 9/13 | A | GlenOak (OH) (5-5) | [1:1] | L | 0-43 | |
| 9/21 | A | Saint Mary's (1-2) | L | 6-21 | ||
| 9/27 | H | Riverside (0-1) | W | 41-0 | ||
| 10/4 | H | Cardinal O'Hara (0-2) | W | 50-21 | ||
| 10/12 | A | Canisius (9-2) | [1:0] | L | 0-24 | |
| 10/18 | H | Williamsville South (0-1) | W | 30-7 | ||
| 10/26 | A | St Joseph's Collegiate (2-4) | L | 6-15 | ||
| 11/1 | H | St Francis (2-4) | L | 6-41 | ||
| 11/7 | H | Saint Mary's (1-2) | W* | 24-7 | ||
| 11/14 | N | Canisius (9-2) | [1:0] | L* | 0-30 | |
| * - game does not count in OHSAA rankings | ||||||