| 8/21 | H | Hancock County (0-2) | W | 50-15 | ||
| 8/28 | H | Evansville Harrison (IN) (0-1) | W | 27-14 | ||
| 9/3 | A | Campbell County (0-2) | W | 57-20 | ||
| 9/17 | A | Elder (OH) (10-2) | [1:4] | L | 14-35 | |
| 9/24 | A | Paul Dunbar (1-1) | W | 59-20 | ||
| 10/2 | A | Covington Catholic (5-6) | W | 45-7 | ||
| 10/8 | A | Scott (Covington) (0-2) | W | 49-21 | ||
| 10/15 | H | Dixie Heights (2-2) | W | 24-6 | ||
| 10/22 | H | Holmes (Covington) (1-2) | W | 63-0 | ||
| 10/29 | H | Conner (0-3) | W | 47-10 | ||
| 11/5 | H | Anderson County (0-1) | W* | 68-14 | ||
| 11/12 | H | Harrison County (1-1) | W* | 62-26 | ||
| 11/19 | H | Dixie Heights (2-2) | W* | 41-24 | ||
| 11/26 | H | Lawrence County (4-1) | W* | 76-36 | ||
| 12/4 | N | Owensboro (0-1) | W* | 48-10 | ||
| * - game does not count in OHSAA rankings | ||||||