| 8/20 | A | Lakota East (7-4) | [I:4] | W | 42-27 | |
| 8/27 | A | Chaminade Julienne (4-6) | [III:12] | W | 42-28 | |
| 8/28 | H | Trinity (Louisville) (KY) (3-6) | [I] | C* | cancelled | |
| 9/3 | A | East Central (IN) (8-2) | [II] | W | 39-22 | |
| 9/10 | A | Ironton (11-2) | [V:19] | W | 25-7 | |
| 9/17 | H | St Xavier (10-3) | [I:4] | L | 16-49 | |
| 9/24 | H | La Salle (7-6) | [II:8] | W | 28-14 | |
| 10/2 | A | Elder (6-6) | [I:4] | L | 58-59 | ot |
| 10/9 | H | St Ignatius (8-5) | [I:1] | W | 29-28 | ot |
| 10/16 | A | St Edward (15-1) | [I:1] | W | 28-21 | ot |
| 10/22 | A | Detroit King (MI) (6-1) | [III] | L | 29-39 | |
| 10/29 | H | # Oak Hills (0-11) | [I:4] | W | 35-14 | |
| 11/5 | H | # Fairfield (6-5) | [I:4] | W | 35-7 | |
| 11/12 | N | # Princeton (11-2) | [I:4] | W | 28-21 | |
| 11/19 | N | # Lakota West (11-2) | [I:4] | W | 21-17 | |
| 11/26 | N | # Springfield (13-2) | [I:2] | L | 21-22 | |
| * - game does not count in OHSAA rankings | ||||||
| # - Ohio playoff game | ||||||